祁贤
作者: 来源:农工党支部 日期: 2016-04-11
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  祁贤(1971,5--),博士,研究员,硕士生导师,江苏省流感省级参比实验室负责人,多年获评省疾控中心年度先进工作者。长期从事流感病毒和发热伴血小板减少综合征病毒的分子遗传进化、分子诊断和分子致病机理等研究。2004年在中国猪群中首次分离新的基因重配H1N2流感病毒,2005年首次在貉体内分离H5N1高致病性禽流感病毒,2011年报道了中国首例人感染欧洲类禽H1N1猪流感病毒病例。

  一、教育经历

  1.19909-1994山西农业大学动物医学院 本科生

  2.19949-1997东北农业大学动物医学院 硕士研究生

  3.20039-2006南京农业大学动物医学院 博士研究生

  4.20067-2008南京大学生命科学学院   博士后

  5.20137-2014加拿大曼尼托巴大学医学院   访问学者

  二、奖励情况

  1.2010年评为江苏省医学重点人才。

  2.2011年入选江苏省第四期“333高层次人才培养工程”第三层次培养对象。

  3.2012年获江苏省预防医学会2004-2012年度优秀科技论文。

  4.2014年评为江苏省“六大人才高峰”培养人员、第一批江苏省“卫生拔尖人才”。

  5.2013年获江苏省卫生厅人感染H7N9禽流感防治工作三等功。

  三、项目获奖

  1.2001年获上海市科学技术进步二等奖

  2.2003年获上海市科学技术进步三等奖

  3.2014年获江苏省医学新技术引进奖一等奖、江苏省医学新技术引进奖一等奖、中华医学科技奖二等奖、江苏省科学技术奖二等奖。

  四、主持课题

  1.江苏省自然科学基金,发热伴血小板减少综合征急性感染相关miRNA鉴定及其抗干扰素分子机制研究(BK20131450) (2013-2016)。

  2.江苏省自然科学基金,RNase P核酶对H5N1 高致病性禽流感病毒复制的抑制作用(BK2009434) 2009-2012)。

  3.江苏省科技厅高技术研究,流行性感冒病毒分型检测基因芯片的研制与开发(BG20077035) 2007-2011)。

  4.中国博士后基金,抑制H5N1 高致病性禽流感病毒复制的RNase P核酶设计 (2006-2008)。

  五、学术兼职

  1.《国际病毒学杂志》第三届编委。

  2.第五届江苏省预防医学会流行病学委员会委员。

  3.第一届江苏省预防医学会微检专业委员会委员。

  六、发明专利

  获得国家发明专利授权3项,专利申请公布9项。

  七、近年来主要论著

  1.      Qi X, Qian YH, Bao CJ, Guo XL, Cui LB, Tang FY, et al. Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. Bmj. 2013;347:f4752.

  2.      Qi X, Cui L, Yu H, Ge Y, Tang F. Whole-Genome Sequence of a Reassortant H5N6 Avian Influenza Virus Isolated from a Live Poultry Market in China, 2013. Genome announcements. 2014;2(5). PubMed PMID: 25212611.

  3.      Qi X, Cui L, Xu K, Wu B, Tang F, Bao C, et al. Avian influenza A(H7N9) virus infection in pregnant woman, China, 2013. Emerging infectious diseases. 2014 Feb;20(2):333-4.

  4.      Qi X, Pang B, Lu CP. Genetic characterization of H1N1 swine influenza A viruses isolated in eastern China. Virus genes. 2009 Oct;39(2):193-9.

  5.      Qi X, Pan Y, Qin Y, Zu R, Tang F, Zhou M, et al. Molecular characterization of avian-like H1N1 swine influenza a viruses isolated in Eastern China, 2011. Virologica Sinica. 2012 Oct;27(5):292-8.

  6.      Qi X, Lu CP. Genetic characterization of novel reassortant H1N2 influenza A viruses isolated from pigs in southeastern China. Archives of virology. 2006 Nov;151(11):2289-99.

  7.      Qi X, Li X, Rider P, Fan W, Gu H, Xu L, et al. Molecular characterization of highly pathogenic H5N1 avian influenza A viruses isolated from raccoon dogs in China. PloS one. 2009;4(3):e4682.

  8.      Qi X, Cui L, Jiao Y, Pan Y, Li X, Zu R, et al. Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011. Archives of virology. 2013 Jan;158(1):39-53..

  9.      Bao CJ*, Qi X*, Wang H. A novel bunyavirus in China. The New England journal of medicine. 2011 Sep 1;365(9):862-3; author reply 4-5.(同等贡献)

  10.   Bao CJ*, Guo XL*, Qi X*, Hu JL, Zhou MH, Varma JK, et al. A family cluster of infections by a newly recognized bunyavirus in eastern China, 2007: further evidence of person-to-person transmission. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2011 Dec;53(12):1208-14.同等贡献) (

  11.   Zhu Y*, Qi X*, Cui L*, Zhou M, Wang H. Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China. Lancet. 2013 Jun 15;381(9883):2134. (同等贡献)

  12.Zhang X*, Qi X*, Zhang Q, Zeng X, Shi Z, Jin Q, et al. Human 4F5 single-chain Fv antibody recognizing a conserved HA1 epitope has broad neutralizing potency against H5N1 influenza A viruses of different clades. Antiviral research. 2013 Aug;99(2):91-9. (同等贡献)

  13.   Wei P, Luo P, Li W, Zi H, Qi X*, Deng F, et al. Emergence of truncated PB1-F2 protein of H3N2 influenza virus during its epidemic period in Jiangsu Province, China. Chinese medical journal. 2014;127(8):1487-92. (通讯作者)

  14.   Guo X*, Qi X*, Cui L, Ge Y, Yu H, Zhu X, et al. Complete Genome Sequence of a Novel Reassortant Avian Influenza H9N9 Virus Isolated from Chicken in Eastern China. Genome announcements. 2014;2(5). 同等贡献)(

  15.   Li Z, Cui L, Zhou M, Qi X, Bao C, Hu J, et al. Development and application of a one-step real-time RT-PCR using a minor-groove-binding probe for the detection of a novel bunyavirus in clinical specimens. Journal of medical virology. 2013 Feb;85(2):370-7.(通讯作者)

  16.   Jiao Y*, Qi X*, Liu D*, Zeng X, Han Y, Guo X, et al. Experimental and Natural Infections of Goats with Severe Fever with Thrombocytopenia Syndrome Virus: Evidence for Ticks as Viral Vector. PLoS neglected tropical diseases. 2015 Oct;9(10):e0004092.同等贡献) (

  17.   Qu B*, Qi X*, Wu X, Liang M, Li C, Cardona CJ, et al. Suppression of the interferon and NF-kappaB responses by severe fever with thrombocytopenia syndrome virus. Journal of virology. 2012 Aug;86(16):8388-401.同等贡献) (

  18.   Jiao Y*, Zeng X*, Guo X*, Qi X*, Zhang X, Shi Z, et al. Preparation and evaluation of recombinant severe fever with thrombocytopenia syndrome virus nucleocapsid protein for detection of total antibodies in human and animal sera by double-antigen sandwich enzyme-linked immunosorbent assay. Journal of clinical microbiology. 2012 Feb;50(2):372-7. 同等贡献)(

  19.   Cui L*, Liu D*, Shi W*, Pan J*, Qi X*, Li X, et al. Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus. Nature communications. 2014;5:3142. (同等贡献)

  Zhou J, Wang D, Gao R, Zhao B, Song J, Qi X, et al. Biological features of novel avian influenza A (H7N9) virus. Nature. 2013 Jul 25;499(7459):500-3.

  20.   Zhao C, Qi X, Ding M, Sun X, Zhou Z, Zhang S, et al. Proinflammatory Cytokine Dysregulation is Associated with Novel Avian Influenza A (H7N9) Virus in Primary Human Macrophages. The Journal of general virology. 2015 Dec 2.

  21     Wang J, Qi X, Lu C. Mutations in the C-terminal tail of NS1 protein facilitate the replication of classical swine H1N1 influenza A virus in mice. Folia microbiologica. 2012 May;57(3):169-75.

  22.   Qi Y, Fan H, Qi X, Zhu Z, Guo X, Chen Y, et al. A novel pyrosequencing assay for the detection of neuraminidase inhibitor resistance-conferring mutations among clinical isolates of avian H7N9 influenza virus. Virus research. 2014 Jan 22;179:119-24..

  23.   Li Y, Wu T, Qi X, Ge Y, Guo X, Wu B, et al. Simultaneous detection of hemagglutinin and neuraminidase genes of novel influenza A (H7N9) by duplex real-time reverse transcription polymerase chain reaction. Journal of virological methods. 2013 Dec;194(1-2):194-6.

  24.   Li X, Qi X, Miao L, Wang Y, Liu F, Gu H, et al. Detection and subtyping of influenza A virus based on a short oligonucleotide microarray. Diagnostic microbiology and infectious disease. 2009 Nov;65(3):261-70.

  25.   He S, Shi J, Qi X, Huang G, Chen H, Lu C. Lethal infection by a novel reassortant H5N1 avian influenza A virus in a zoo-housed tiger. Microbes and infection / Institut Pasteur. 2015 Jan;17(1):54-61.

  26.   Gu H, Qi X, Li X, Jiang H, Wang Y, Liu F, et al. Rapid and specific detection of H3 swine influenza virus using reverse transcription loop-mediated isothermal amplification method. Journal of applied microbiology. 2010 Apr;108(4):1145-54.

  27.   Ge Y, Wu B, Qi X, Zhao K, Guo X, Zhu Y, et al. Rapid and sensitive detection of novel avian-origin influenza A (H7N9) virus by reverse transcription loop-mediated isothermal amplification combined with a lateral-flow device. PloS one. 2013;8(8):e69941. PubMed PMID: 23936359.

  28.   Ge Y, Cui L, Qi X, Shan J, Shan Y, Qi Y, et al. Detection of novel swine origin influenza A virus (H1N1) by real-time nucleic acid sequence-based amplification. Journal of virological methods. 2010 Feb;163(2):495-7.

  29.   Xing Z, Schefers J, Schwabenlander M, Jiao Y, Liang M, Qi X, et al. Novel bunyavirus in domestic and captive farmed animals, Minnesota, USA. Emerging infectious diseases. 2013;19(9):1487-9..

  30.   Wu X, Qi X, Liang M, Li C, Cardona CJ, Li D, et al. Roles of viroplasm-like structures formed by nonstructural protein NSs in infection with severe fever with thrombocytopenia syndrome virus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014 Jun;28(6):2504-16..

  31.   Li Z, Qi X, Zhou M, Bao C, Hu J, Wu B, et al. A two-tube multiplex real-time RT-PCR assay for the detection of four hemorrhagic fever viruses: severe fever with thrombocytopenia syndrome virus, Hantaan virus, Seoul virus, and dengue virus. Archives of virology. 2013 Sep;158(9):1857-63.

  32.   Cui L, Ge Y, Qi X, Xu G, Li H, Zhao K, et al. Detection of severe fever with thrombocytopenia syndrome virus by reverse transcription-cross-priming amplification coupled with vertical flow visualization. Journal of clinical microbiology. 2012 Dec;50(12):3881-5.

  33.流行病学(第二版),2015,人民卫生出版社,参编。

  34. 实验动物替代方法原理与应用,2012, 科学出版社,参编。